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INFACT Canada Spring 1996 Newsletter Abstracts


Early diet of preterm infants and bone mineralization at age five years
N. J. Bishop et al. Acta Paediatr 85:230-236, 1996

lthough bone disease due to decreased bone mineralization is common among preterm infants, this retrospective study explores the bone growth and mineralization at the age of 5 years in infants born preterm, and assigned different type of milks as supplements to their own mother's milk during early weeks post partum. Fifty-four children averaging 5 years, who had received preterm infant formula or banked pasteurized donor human milk as supplement to their own mother's milk during their early weeks were tested for bone mineral content. This study concluded that the greater the intake of human milk, the higher the later bone mineral content, suggesting that the early nutritional environment of preterm infants plays an important role in long term bone growth and mineralization. Two mechanisms for this are proposed. Firstly, that early mineral depletion "programmes" preterm infants to conserve bone mineral and to limit growth to a time when mineral intakes are normal when increased growth can occur. The second possibility is that one or more of the growth hormones present in the donor milk survives pasteurization and is active in producing the higher bone mineralization. The authors recommend further studies on the impact of diet in early life to determine long term effects such as the propensity to develop diseases such as osteoporosis.

Use of Pacifiers is Associated With Decreased Breast-Feeding Duration

F. C. Barros et al. Pediatrics 95:497-499, 1995

he widespread use of pacifiers, both in developing countries and in industrialized counties has led to broad concerns regarding "nipple confusion", decreased lactation and early weaning from the breast. Since decreased breastfeeding correlates with increased infant mortality in poor societies, these researchers felt a need to determined the relationship between the use of pacifiers and breastfeeding duration. This longitudinal study followed 605 infants born in Sao Paulo, Brazil from the age of 1 month to 6 months to determine the duration of breastfeeding. Results showed that non-users of pacifiers were more likely to breastfeed exclusively. Increased use of pacifiers at 1 month increased the risk for being weaned by 4 months. The authors suggest that pacifiers should not be used for breastfed infants.

A Large-scale, Hospital-based Case-Control Study of Risk Factors
of Breast Cancer According to Menopausal Status
K. Hirose et al. Jpn. J. Cancer Res. 86:146-154, 1995

reast cancer rates in most Asian counties, although traditionally lower than Western countries, are experiencing a marked increase in recent years. This large Japanese study, to elucidate the variousrisk factors of breast cancer according to pre or post-menopausal status used self-administered questionnaires to collect data from 37,882 hospital patients between 1988 to 1992. The case group consisted of 1,186 women with breast cancer, and 23,163 free from cancer were selected as the control group. A number of factors such as diet, physical activity, family history, smoking and drinking were studied. The researchers found a statistically significant protective effect of lactation for premenopausal women who breastfed more than 6 months.


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